The House of the Dead (1996)
Main article: The House of the Dead (arcade game)

On December 18, 1998, the insane and disillusioned Dr. Curien plans to mobilize his armies of undead unto the unsuspecting populace. AMS agents Thomas Rogan and "G" are dispatched to his mansion to put a stop to the madman and rescue Sophie Richards, Rogan's fiancée.

The House of the Dead 2 (1998)
Main article: The House of the Dead 2

On February 26, 2000, Goldman, the man behind the Curien Mansion case, claims responsibility. Fueled by his detest of humankind's complete lack of responsibility toward its assigned task, Goldman initiates an attack on Venice while his Emperor project develops. Two new agents named James Taylor and Gary Stewart are sent in to tackle this case.

The House of the Dead III (2002)
Main article: The House of the Dead III

In the post-apocalyptic world of 2019, Thomas Rogan and his team of commandos infiltrate the EFI Research Facility in hopes of finding the source of the planet's collapse. Losing contact with him, daughter Lisa Rogan and former partner "G" set out on a search and recover mission, unaware that what awaits them has ties to the distant past and the very genesis of the undead horde.